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Transcript
00:00which happens to cells and leads to these serious consequences, not only for the algal lateral sclerosis disease,
00:08It's about a number of neurological diseases
00:11That could affect the brain.
00:14Here at the University of Ninety Centers for Technology, we go to researcher Brenni La in Tunisia, Tasst Hadar
00:20which has been pursuing its research on wrong proteins for a long time.
00:25We often use this to simulate the evolution of proteins. Proteins are usually folded to form a pressurized structure that works effectively.
00:34But sometimes it folds wrong.
00:37Which could lead to serious consequences. It may seem simple, but how do these proteins evolve? It's what might affect him.
00:47It highlights many diseases that can infect the brain.
00:50This is important in many diseases, such as the disease of Pakistan, Alzheimer's, Heston's disease, and algal lateral sclerosis and diabetes, which occur with age. Here the proteins go wrong and they stick together.
01:05If we come to an understanding of the principles of this process
01:08We might be able to cure her. All the diseases
01:12All of the cells in the human body contain proteins, which are the positive factor that performs the difficult tasks inside the cell,
01:22But it has to be right. When proteins form, they fold specifically. But as Brunel says, no
01:31Proteins can sometimes be twisted wrong
01:34And then she won't be able to do her job.
01:37And what's even worse is the risk of sticking it to other proteins, components of huge blocks that are capable of killing the cell.
01:45I want to understand the mechanism of protein development and volunteering
01:51Let's figure out a way to stop the diseases caused by the wrong pilot.
01:57Brenni's team develops only a kind of sit-in that produces proteins
02:03They believe that the reason Parkinson's disease in the lab tests several ways to affect these proteins.
02:12We mix the protein with many things to understand the mechanism of its impact on the bad evolution and whether it's going to accelerate or stop it.
02:22Brunel's team uses spectroscopy to see how proteins can affect the folding
02:31The result appears in the form of curves. This method shows the formation or shape of the protein.
02:36We see in the green model here an unfolded protein with no specific structure. In the blue form, we have a folding protein
02:46We're wrongly folding the protein in, it's going to join other poorly developed proteins, too.
02:54So when they stick together, they form