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Throughout her career, Christina Applegate has used her platform to shine a light on the health challenges she and others face — helping to raise awareness both in Hollywood and beyond.

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Christina Applegate recalls 'screaming' in pain amid health struggles with multiple sclerosis
Bang Showbiz Extra
1:23
Christina Applegate Reveals She Was Diagnosed with Multiple Sclerosis 'A Few Months Ago'
People
0:46
Christina Applegate Went Barefoot For Her First Public Appearance Since M.S. Diagnosis
Instyle
2:34
Christina Applegate Makes Emotional First Public Appearance After MS Diagnosis: 'I Love You Al - 1br
1BN-RADIO
1:19
Christina Applegate's Last Appearance After Diagnosis
Allvipp.com
0:53
Christina Applegate says reality shows help her cope with MS diagnosis
Bang Showbiz
1:10
Christina Applegate's ex praises her as 'toughest human being'
Bang Showbiz
1:25
Christina Applegate regrets lying about how she felt during her battle with breast cancer
Bang Showbiz
0:42
Christina Applegate's Inspiring Emmy Moment
SKEntertainment
1:14
Christina Applegate got plastic surgery to remove eye bags
Bang Showbiz
1:19
Christina Applegate got plastic surgery to remove 'big' eye bags
Bang Showbiz
1:13
Christina Applegate left in a 'f*** it' style depression because of her MS
Bang Showbiz Extra
1:29
Christina Applegate was invited to join 'The Real Housewives of Beverly Hills' a decade ago
Bang Showbiz
0:50
Angelina Jolie's Hollywood Exit
SKEntertainment
1:46
Christina Applegate Finally Opened About Her Condition MS
LehrenDotCom
1:21
Christina Applegate Reveals Multiple Sclerosis Diagnosis | THR News
The Hollywood Reporter
1:52
Christina Applegate Slams Candace Owens’ Criticism of Underwear Ad Featuring Model in Wheelchair | THR News
The Hollywood Reporter
0:48
Christina Applegate breaks down as Emmys audience give her standing ovation
The Independent
1:21
Christina Applegate has candidly admitted having multiple sclerosis has led to her wearing diapers
Bang Showbiz
0:34
Jennifer Garner Calls Her Star on the Walk of Fame "Surreal"
E! Entertainment UK
1:56
Angelina Jolie Breaks Silence on Brad Pitt in 'Vanity Fair' Cover Story | THR News
The Hollywood Reporter
6:25
Angelina Jolie: "There Is So Much We Have to Change and Fight For" | Women in Entertainment 2017
The Hollywood Reporter
1:22
Christina Applegate and More Speak Out on On Donald Trump Winning the Presidential Election
What's Trending
1:27
Christina Haack Reveals She Has Mercury and Lead Poisoning After Years of ‘Flip or Flop’ Renovations
US Weekly
1:31
Meredith Vieira Says She and Husband Richard Cohen Vent Frustrations About His MS
People