AI_failed_AlphaFold_s_AI_Not_a_Cure-All__High_Schoolers_Challenge_DeepMind_s_Protein_Physics_Mastery(720p)

A recent bioinformatics boot camp for high school students at Skoltech turned into a venue for the latest chapter in the ongoing contest between humans and artificial intelligence in science. Google's DeepMind AlphaFold program previously solved a 50-year-old problem of predicting protein structures. However, a recent PLOS One study found that AlphaFold was unable to predict the impact of single mutations on protein stability, a central task of structural bioinformatics. The study's principal investigator stated that this finding refutes claims by AlphaFold enthusiasts that the AI program has mastered the ultimate protein physics. The study also highlights several major challenges that remain in structural bioinformatics, reminding scientists that AI is not a cure-all.