• 2 months ago
Dangerous new strains of a "hypervirulent" superbug have been found in 16 countries, including the United States, the World Health Organization (WHO) announced in a new report.

The superbug, known as hypervirulent Klebsiella pneumoniae (hvKp), is a type of drug-resistant bacteria that can cause rapidly progressing, deadly infections, even in people with healthy immune systems.

In general, K. pneumoniae can be found in the environment — for example, in soil and water — as well as in the upper throat and gastrointestinal tract of various animals, including humans. The classic version of the germ is a big problem in health care settings, where it can contaminate medical equipment and cause opportunistic infections, especially in people with weak immune systems. It's known to cause pneumonia, urinary tract infections, bloodstream infections and the nervous-system infection meningit
At baseline, the bacteria are inherently resistant to the antibiotic ampicillin, and in recent years, they've developed resistance to more and more drugs.

Related: Superbugs are on the rise. How can we prevent antibiotics from becoming obsolete?

The newer, "hypervirulent" variety of K. pneumoniae poses a wider threat because it can cause severe infections even in people with healthy immune systems. The invasive infections can progress very quickly, spurring a high rate of complications and death, according to CIDRAP News, which is published by the University of Minnesota.

When these hvKp strains were initially discovered in Asia in the 1980s, they were still vulnerable to a variety of antibiotics. But now, the strains have spread globally and show resistance to both older and newer classes of antibiotics, studies suggest. In particular, it's concerning that some of these strains show resistance to carbapenems, a class of antibiotics often used to treat bacterial infections that are resistant to multiple other drugs.
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00:00Dangerous new strains of a hypervirulent superbug have been found in 16 countries, including
00:07the United States, the World Health Organization, WHO, announced in a new report.
00:14The superbug, known as Hypervirulent Klebsiella Pneumoniae, HBKP, is a type of drug-resistant
00:21bacteria that can cause rapidly progressing, deadly infections, even in people with healthy
00:27immune systems.
00:28In general, K, pneumoniae can be found in the environment, for example, in soil and
00:35water, as well as in the upper throat and gastrointestinal tract of various animals,
00:41including humans.
00:42The classic version of the germ is a big problem in healthcare settings, where it can contaminate
00:48medical equipment and cause opportunistic infections, especially in people with weak
00:53immune systems.
00:55It's known to cause pneumonia, urinary tract infections, bloodstream infections, and the
01:00nervous system infection meningitis.
01:03Sponsored links
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01:11CPX
01:13At baseline, the bacteria are inherently resistant to the antibiotic ampicillin, and in recent
01:19years, they've developed resistance to more and more drugs.
01:23As stated, superbugs are on the rise.
01:26How can we prevent antibiotics from becoming obsolete?
01:29The newer, hypervirulent variety of K, pneumoniae poses a wider threat because it can cause
01:36severe infections even in people with healthy immune systems.
01:40The invasive infections can progress very quickly, spurring a high rate of complications
01:46and death, according to Sidrap News, which is published by the University of Minnesota.
01:52When these HVKP strains were initially discovered in Asia in the 1980s, they were still vulnerable
01:59to a variety of antibiotics.
02:02But now, the strains have spread globally and show resistance to both older and newer
02:07classes of antibiotics, studies suggest.
02:11In particular, it's concerning that some of these strains show resistance to carbapenems,
02:16a class of antibiotics often used to treat bacterial infections that are resistant to
02:22multiple other drugs.
02:24The WHO's report is a result of the agency requesting information from its member states
02:29regarding the global prevalence of K, pneumoniae.
02:33The request yielded data from 43 countries and territories.
02:38Of those, 16 reported detecting HVKP.
02:42Twelve of the reporting countries said they'd found a particularly concerning strain of
02:47the bacterium dubbed ST23, which carries genes that enable it to resist carbapenems and all-available
02:54beta-lactam antibiotics, the WHO said in a July 31 statement.
02:59The U.S. was among the countries that reported detecting HVKP bacteria, in general, but not
03:05ST23, specifically.
03:08Globally, the prevalence of HVKP-associated infections may be underestimated due to current
03:15limitations in the surveillance for these germs, the WHO said in the statement.
03:20The agency flagged a need to improve awareness about these infections and to expand testing
03:25for them.
03:26That's important for tracking the superbug within the population as a whole and for treating
03:31individual patients, because correctly identifying the bacteria is important for selecting the
03:37correct treatment course, the agency said.
03:40With the concurrence of hypervirulence and antibiotic resistance, it is expected that
03:46there will be an increased risk of spread of these strains at both the community and
03:50hospital levels, the WHO concluded.
03:53Ever wonder why some people build muscle more easily than others, or why freckles come out
03:58in the sun?
03:59Send us your questions about how the human body works to communityatlivescience.com with
04:04the subject line, Health Desk Q, and you may see your question answered on the website.

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