U.S. clinic to provide uterus transplants to help women get pregnant
- 9 years ago
CLEVELAND — A team in Ohio is spearheading an experimental surgery, the first of its kind in the U.S., that may prove to be significant for infertile women wishing to carry a baby to full term.
The New York Times reports that the Cleveland Clinic is starting trials for a uterine transplant procedure that could help some 50,000 women born without a uterus or with uterus problems, get pregnant.
The team began screening candidates in September. Ten women, aged 21-39, will undergo the procedure following extensive medical and psychological evaluation. Once a patient is approved for the procedure, she is given hormones to stimulate egg production. Multiple eggs are fertilized in vitro and the embryos are frozen.
When a suitable donor is found, the uterus, cervix, and part of the vagina is removed and must be transplanted into the pelvis within six to eight hours. The uterus is connected to the recipient's vagina, and the uterine vessels, normally wound around the ureters, are redirected to the larger blood vessels around the pelvis.
A year later, embryos are implanted one at a time into the fully-healed uterus until the patient becomes pregnant. After giving birth to one or two babies via C-section, the transplanted uterus will be removed to prevent patients from having to continuously take anti-rejection drugs, according to the Cleveland Clinic.
In Sweden, nine uterine transplants from live donors resulted in five pregnancies and four live births. In the U.S., deceased organ donors will be used to minimize complications.
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The New York Times reports that the Cleveland Clinic is starting trials for a uterine transplant procedure that could help some 50,000 women born without a uterus or with uterus problems, get pregnant.
The team began screening candidates in September. Ten women, aged 21-39, will undergo the procedure following extensive medical and psychological evaluation. Once a patient is approved for the procedure, she is given hormones to stimulate egg production. Multiple eggs are fertilized in vitro and the embryos are frozen.
When a suitable donor is found, the uterus, cervix, and part of the vagina is removed and must be transplanted into the pelvis within six to eight hours. The uterus is connected to the recipient's vagina, and the uterine vessels, normally wound around the ureters, are redirected to the larger blood vessels around the pelvis.
A year later, embryos are implanted one at a time into the fully-healed uterus until the patient becomes pregnant. After giving birth to one or two babies via C-section, the transplanted uterus will be removed to prevent patients from having to continuously take anti-rejection drugs, according to the Cleveland Clinic.
In Sweden, nine uterine transplants from live donors resulted in five pregnancies and four live births. In the U.S., deceased organ donors will be used to minimize complications.
-------------------------------------------------------------
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