Consultant urologist Dr George Lee Eng Geap, or a.k.a Dr G, explains what the side effects that the first generation of blue pill, also known as sildenafil, may induce. He points out that one will experience “blue vision” after taking the pill.
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NewsTranscript
00:00 Hello there, welcome to another episode of putting Dr. G on the spot in the month of
00:05 March and we're approaching the 27th of March.
00:08 Actually, what's the significance of that day?
00:11 It is the day when the blue pill was first introduced in 1998.
00:18 Imagine 26 years down the line, initially all that fear about how this drug can cause
00:25 havoc in health and also society hasn't really happened and it actually stood the test of
00:32 time.
00:39 Exactly what are the effects of this medication as far as efficacy is concerned?
00:46 Actually for 70 to 80% of men who take this pill, the erection can actually be restored.
00:54 However, what are the side effects you ask?
00:57 In fact, curiously there are a few very unique side effects of this blue pill.
01:03 First of all, for people who take this, they always get these hot flushes.
01:08 Why does it happen?
01:09 It's because of dilation of the vessel.
01:13 Effectively, this drug is a vasodilator.
01:17 When it causes the dilations of the vessel, some people will get hot flushes and also
01:23 headache.
01:24 That is probably the commonest side effects somebody can expect.
01:29 The second issue that the medication can induce is this indigestion.
01:35 Because it's a vasodilation, it relaxes the smooth muscle and there is an acid reflux
01:42 that can induce for somebody, especially if you've got obesity.
01:47 And lastly, a very, very curious side effect that is very unusual, it's called the blue
01:54 and blurred vision.
01:56 So exactly how it works is that there is a cross reaction of phosphodiesterase 5 and
02:04 phosphodiesterase 6.
02:06 And that 6 occurs in the retina and that interaction will cause the difficulty in differentiation
02:14 between blue and green.
02:17 As a result of that, the activation of retina actually induces some sort of blue vision
02:23 and that itself also causes some sort of blurred vision.
02:27 Some men who take the pills reckons that the blue pills and the blue materials has gone
02:32 to the eye and then a bit of guilty conscience thinks that they're probably going to go blind.
02:38 However, thank goodness that is not the case.
02:41 People often ask me, is there an absolute contraindication to the blue pills?
02:46 Yes, there is.
02:47 There are two conditions that you're not allowed to take the pill.
02:51 Number one, if you're on nitrites, GTN for your angina, no, no.
02:56 And number two, if you've got a genetic condition called retinitis pigmentosa, then you're not
03:03 really suitable to take the pill.
03:05 For next week, we're going to explore the possibility of cure for ED.
03:10 Of course, you've heard of all sorts of technology that potentially can cure ED.
03:16 And more interestingly, if you're interested to find out whether the blue pill can cure
03:20 ED, then stay tuned for Putting Dr. G on the Spot next week.
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