(Adnkronos) - Velocità d’azione caratteristica predominante. 'Assunti per via orale, e con un buon profilo di sicurezza, sono efficaci già nelle prime 24-48 ore’.
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00:00The inhibitor jacks have changed the approach to the management of atopic dermatitis
00:10because the characteristic of the inhibitor jack is the speed.
00:14They have an on-off mechanism, like a switch,
00:18when the therapy is taken, it is a pill therapy,
00:22compared to biopharmaceuticals that are injectable,
00:25when it is taken, already in the first 24,
00:28on average 48 hours, you can see the effect of the therapy.
00:32In fact, patients refer in the first 48 hours
00:36to the disappearance of pruritus,
00:38which is the most important symptom of atopic dermatitis,
00:41the most invalidating for the patient,
00:43and already in the first month,
00:46a partial and progressive disappearance of signs of dermatitis.
00:52So it is the rapidity, the characteristic effect,
00:56and a rapidity that is also a sign of effectiveness,
01:00in the sense that we must not think that they are fast,
01:03but then after a certain period of time they do not work,
01:07because this rapidity has then been shown to be maintained even in the long term.
01:12There are data of over 140 weeks for studies, two years,
01:17that show how the rapidity of action on the sign and on the symptom
01:22is then maintained over time.
01:24So we can say that they are fast,
01:26but they are also constant in the effect they produce for the patient.
01:31The data that we have, the Italian experience,
01:34shows us how, but this is a daily experience,
01:37how in reality they are absolutely manageable drugs,
01:41with a good safety profile,
01:44that allow us to manage our patients,
01:47who are sometimes also complex patients.
01:49So all the alarmism that there was at first,
01:52compared to inhibitors,
01:54certainly did not affect the experience of Italian dermatologists,
01:58who enthusiastically accepted this therapy,
02:01and indeed this enthusiasm was then translated into a clinical practice
02:06that confirmed what we saw a little bit from the trials,
02:10and, let's say, removed some doubts on something,
02:13on some topic that could generate some concern.