(Adnkronos) - In questo numero:
Terapie e cultura trasformano la vita dei pazienti con emofilia
Approvato in Europa delgocitinib di Leo Pharma per eczema cronico delle mani da moderato a grave
Oltre il buio e il silenzio: la Lega del Filo d’Oro celebra i 60 anni di attività
Salutequità presenta le ‘Sette leve’ per un Servizio sanitario nazionale equo e sostenibile
Giornata mondiale della prematurità, 25.000 le nascite pretermine in Italia, il 96% sopravvive
A Roma si fa squadra attorno al diabete con FeSdi
Via libera di Aifa a fenfluramina per la sindrome di Lennox - Gastaut
Al via campagna social ‘Oltre il labirinto della depressione’
Dal Pnrr iniezione di investimenti e innovazione
Neurologia, assegnato il premio Merck per l’innovazione digitale
Terapie e cultura trasformano la vita dei pazienti con emofilia
Approvato in Europa delgocitinib di Leo Pharma per eczema cronico delle mani da moderato a grave
Oltre il buio e il silenzio: la Lega del Filo d’Oro celebra i 60 anni di attività
Salutequità presenta le ‘Sette leve’ per un Servizio sanitario nazionale equo e sostenibile
Giornata mondiale della prematurità, 25.000 le nascite pretermine in Italia, il 96% sopravvive
A Roma si fa squadra attorno al diabete con FeSdi
Via libera di Aifa a fenfluramina per la sindrome di Lennox - Gastaut
Al via campagna social ‘Oltre il labirinto della depressione’
Dal Pnrr iniezione di investimenti e innovazione
Neurologia, assegnato il premio Merck per l’innovazione digitale
Category
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NewsTranscript
00:00In this issue, therapy and culture transform the lives of patients with haemophilia, approved in Europe by Delgo Citinib, of Leofarma Veret Zema Cronico delle Mani, from moderate to severe.
00:21In addition to darkness and silence, the League of Filodoro celebrates 60 years of activity.
00:26Health and Equity presents the seven levers for an equitable and sustainable SSN.
00:31And again, World Prematurity Day, 25,000 preterm births in Italy, 96% survive.
00:38In Rome, there is a team around diabetes with parties.
00:41Via Libera di Haifa, Affem Fluramina for Lennox-Gastaut syndrome.
00:46Via Campagna Social, beyond the labyrinth of depression.
00:49From PNRR, injection of investments and innovation.
00:52Neurology, awarded the Merck Award for digital innovation.
01:01It was held in Milan, at the headquarters of Sobi Italia, the Sobi Let's Talk Mont Blanc Experience to the Next Level meeting.
01:08The fourth appointment of the Let's Talk project, born last October, with the aim of deepening current and unexplored perspectives in a context, for some aspects still little known, such as rare diseases.
01:22The meeting was dedicated to hemophilia, a rare pathology of coagulation of genetic origin, which causes hemorrhages, even serious, and microblood at the joint level.
01:33In Sobi, we always try to make a difference, listening to those who are still unsatisfied needs of people living with a rare pathology.
01:42Those who are also called unmet needs, with the aim of improving their quality of life.
01:48Today, the joints of patients with hemophilia are more protected, thanks to a correct prophylaxis, to a monitoring of these joints, and also to therapies that are more and more effective.
02:00As well as important is also a continuous, accurate and correct information, not only for people with hemophilia, but also for their families and their caregivers.
02:11Sobi, in collaboration with Save One Life Foundation, has recently supported a group of people with hemophilia, in an exciting and extraordinary adventure, towards the top of Mount Blanc.
02:22The reason that we engaged in this project around Mount Blanc, we were approached about...
02:53...and we felt that it would be an opportunity to inspire the community, and to help to produce a change in thinking, according to which, with hemophilia, you have to stay at home, where you can't take risks, and you can't do physical activities.
03:11An unforgettable experience that has remained in the heart of those who participated.
03:14It was a beautiful experience, also because I have never climbed, and so, from nothing, to start, to reach over 4,000 meters, is a goal that can be achieved with a therapy, a training, and to know your own limits, not to exceed.
03:45The European Commission has granted permission for commercial admission for Delgocitinib, the first cream for the treatment of adult patients with chronic eczema of the hands from moderate to severe, for which corticosteroids are inadequate or inappropriate.
04:00The approval of the European Community is valid in all EU member states, as well as in Iceland, Norway and Liechtenstein.
04:07Announced by Leofarma, the world leader in medical dermatology.
04:11The pathology we are talking about is an invalidating pathology, not only from a purely clinical point of view, but also for the psychological impact it can have.
04:20The research has led to a therapeutic solution that will be innovative and will try to satisfy that need, which is still unsatisfied in Manapeso.
04:28Because the organ referred to is the skin, the skin is clearly a visible organ, so the life is not only professional, but also of a strongly impacted relationship.
04:38So any deviation from what is a healthy skin involves social, clinical and also, why not, expensive impacts in terms of expenses.
04:49Leofarma has always been committed to dermatology. Leofarma is a fairly young company in our country, about 12 years ago we formed Leofarma Italia, a company with 108 years of history.
05:01108 years spent in this area of medicine, which are dermatological pathologies.
05:06We talked about chronic eczema of the hands, but there are others, we are committed to psoriasis, to atopic dermatitis.
05:14We are also pushing to look for solutions in rare diseases and we want to be a reference point for dermatologists.
05:21We have been in the past, we are now, we will be in the future. So a reference point for this specialty.
05:28Chronic eczema of the hands is in fact an inflammatory skin disease with different causes.
05:34It is characterized by a clinical course, for the most chronic, recidivist and for the presence of subjective symptoms such as pruritus and severe pain.
05:42It manifests itself on hands and wrists with lesions such as erythema, edema and vesicles in the acute phase and squamation, lichenification, hyperkeratosis and rhagae in the chronic phase, with serious consequences.
05:54Underlines Professor Luca Stingeni, Director of the Complex Structure of Dermatology of the Department of Medicine and Surgery of the Santa Maria della Misericordia Hospital of Perugia on the quality of life of those who suffer.
06:06The 70% of individuals affected by chronic eczema of the hands, in fact, refers to difficulties in the performance of daily activities and serious repercussions on their work activities due to the pathology.
06:18Thanks to this new drug, however, something has changed. But what is it about? How does it work? And what benefits does it give?
06:25Bugidinib is a molecule that will mark an important turning point in the treatment of patients affected by chronic eczema of the hands,
06:35because it is a drug with a mechanism that we call JAKSTAT, that is, a mechanism of transduction of the inflammatory signal,
06:45which blocks many of the mechanisms that then lead to the production of these inflammatory molecules, which are directly responsible for damage at the acute level.
06:58Delgocidinib, being a pan-JAKSTAT, acts on many mechanisms that then lead to the formation of these inflammatory signals on different aspects of our immunity.
07:10This is the reason why the drug, in Phase 1 and 2 studies, conducted in 16 weeks, but also in the longest study, 32 weeks,
07:23and the results of the Phase 3 studies, in 16 weeks, were recently published on Lancet.
07:33Indeed, I am honored to be one of the authors of this article.
07:38They have shown the achievement of all the endpoints that appeared among the primary objectives of the study.
07:50The League of the Golden Thread has always been on the side of the blind and affected by sensory pluridisability.
08:02The League of the Golden Thread has celebrated in Rome its 60 years of activity, also presenting the new campaign with the title
08:0960 years we do not celebrate, we do together. Rossano Bartoli, who presides over it, has thus commented on this achievement.
08:16The 60 years of the League of the Golden Thread represent an important event at the national level for the life and future of people who live under the condition of blindness.
08:30The first years were pioneering years, like all organizations, where an activity was born, starting with organizing summer holidays,
08:40until the first center was built in Le Marche and so on in 11 Italian regions.
08:46This means that, thanks to the commitment and passion of many, but also to the solidarity of our supporters, we were able to grow and develop the services.
08:59The League of the Golden Thread carries out its activities thanks to the work of volunteers and collaborators and to the support provided by the donations of its supporters.
09:08The mission of the League has been shared and promoted by public figures such as Neri Marcoretti for years.
09:13I am a witness to the thanks to my friend Renzo Arbore, who has been for many years before and who wanted to double this role.
09:25We are a kind of guarantors for the people who donate to the League of the Golden Thread, telling them that everything you donate ends up helping blind people.
09:39You realize the condition of these people and then it becomes easier and more natural to try to do something to help them.
09:51Getting in touch with the League can change the fate of a blind person.
09:55This is the case of Francesco, a boy born with a rare pathology of genetic origin, Norwegian syndrome.
10:02Francesco, as his mother Anna Maria tells us, achieved important goals after being welcomed and followed by the Center of the League of the Golden Thread in Osimo, Marche.
10:11The meeting with the League of the Golden Thread was important because it taught us, our parents, first of all, to be able to have a channel of communication with him.
10:21They introduced a communication called objective communication and he, with these objects, manages to give us the opportunity to understand what he wants at that moment.
10:33For Francesco, therefore, it was also very important for us to meet the League of the Golden Thread precisely because it put us in communication and put Francesco in communication with the world.
10:44The League of the Golden Thread Foundation is a philanthropic entity present in 11 Italian regions with services, territorial headquarters, residential centers and urns, through which it provides diagnostic, educational, rehabilitative and socio-educational support.
10:59Last year it reached the record of followed users, which are currently over 1,200.
11:05In the course of the annual Summit of Health and Equity held in Rome, the new report on the sustainability of the National Health Service was presented.
11:19A text that traces a strategic path to guarantee equity and universal access to care, trying to respond to all current challenges.
11:26During the Summit, it was discussed the necessary resources for the next few years to be allocated to health care because, as the organizers point out, it is insufficient to allocate 136.5 billion euros without a clear strategy.
11:39It is unsustainable to commit such important resources without having a strategic plan, an industrial plan for the public health service.
11:49What is this plan? It is the national health plan that we have not had since 2006-2008.
11:56The other big plan was the Health Pact, even there we are still standing. We must know on which priorities to put these 136.5 billion euros because today we do not have it.
12:09At the Health and Equity Summit, the highest levels of national and regional health, but also the main scientific and civic stakeholders, participated.
12:19They discussed the necessary model that can guarantee a sustainable, equal and responsive national health service to the needs and continuous evolution of society,
12:28so that the defense of equal and universal health can become one of the priorities in the discussion of the law of balance.
12:35The government allocated for this year the 0.4% of the national health fund, 520 million euros.
12:43We have introduced a series of corrective measures with the waiting list decree.
12:48All this constitutes for the Meloni government and for Minister Schillaci an extraordinary moment of confrontation with the regions
12:57to make health more accessible with, evidently, also in the medium and long term, a savings for the funds of the national health fund.
13:07The proposals discussed in the course of the appointment are articulated in seven levels, each of which identifies concrete actions to deal with those that have been identified
13:15as the main challenges of the national health service, useful to respond to the needs of the population.
13:22I believe that the time has come to redefine a governance between the state and the regions, without taking anything away from the regions,
13:31but the part of the state must resume to make a national health plan.
13:37Sustainability also passes through the maintenance of the system and the programming made in time of the various productive factors,
13:48including the programming of staff, which we have seen that in recent years has been missing.
13:53We also need to redistribute the resources from the regions in a more equitable way.
13:58We need to greatly increase the ability to monitor and control the Ministry of Health on the operation of the regions
14:07on many points of view, on the level of essential assistance, on the waiting lists, on access to technologies, pharmaceutical innovation, medical devices.
14:16In short, we really have a lot of things to put in place and we hope that, starting from this balance sheet that is being discussed, these levers can be used.
14:34Every year, more than 13 million children in the world are born prematurely, that is, before the 37th week of pregnancy, equal to 1 in 10.
14:41In Italy, about 25,000.
14:43The survival percentage of hospital admissions is very high, equal to 96%.
14:48On the occasion of the World Prematurity Day, which this year has as climax access to quality care everywhere,
14:54the Italian Society of Neonatology spreads the data of the InSyn-Italian Neonatal Network,
15:00which has seen the participation of 95 neonatal centers in 14 regions, plus the center of the province of Trento,
15:07with 9,543 born prematurely enrolled for a total of 214,071 full-time days, with an average of 22.4 days per patient.
15:17Well, 22.3% of the little ones were born very early, before Thursday of the 32nd week,
15:2316% moderately early, between the 32nd and 33rd week, and 61.7% slightly early.
15:31Only 19.8% has been admitted with exclusive maternal feeding.
15:35This is a very important aspect for the InSyn.
15:37Maternal milk is in fact the priority element to build the future in health of newborns,
15:41underlined by the Italian Society of Neonatology, and even more so for premature newborns,
15:46for whom it constitutes a real life saver.
15:48In the absence or waiting of the milk of their mother, the donated human milk becomes fundamental for this category of newborns,
15:54collected in 44 banks of donated human milk distributed throughout the national territory.
15:59Only 6.3% of the newborns were born in a first-level center,
16:03so a subsequent transfer to a second-level center was necessary,
16:07as a demonstration of a good application of the practice of transfer in utero.
16:11As underlined by the newly elected president of the InSyn, Massimo Agosti.
16:15The premature newborn is a more fragile newborn, more in need of assistance and more in need of care,
16:22not only from nurses but also from his family.
16:26Having understood how important the involvement of the family, the mother and the father in care,
16:34also in intensive care, has led to a great advancement in the quality of care itself.
16:40So, the involvement of the family from the outset in intensive care,
16:44the opening of intensive care throughout the day, day and night, 24 hours a day,
16:51and great availability by the nursing staff to welcome parents as a therapeutic tool of care.
17:00The newborns are better cared for in the presence of their parents.
17:05In a context of constant improvement of care for births,
17:09premature births still have an important impact on neonatology and neonatal intensive care,
17:15on the families involved and on the network of social and educational services.
17:19All this leads to more and more follow-up by our neonatal intensive care.
17:25The European assistance standards lead to a great further advancement of care.
17:31Care that must be carried out in intensive care and then before resigning,
17:37but also after resigning on the territory with the assistance care carried out in the follow-up,
17:45in the ambulatories in which they will be followed, together with the pediatricians of the territory.
17:51Among the proposals of the SIN for the World Prematurity Day 2024,
17:56the new digital purple mini-kit to explain to children what it means to give birth prematurely.
18:01And prematurity for me, small creatives grow.
18:04An initiative designed to create a moment of information, sharing and participation on this condition.
18:09Sunday, November 17, on the occasion of this special event,
18:12responding to the invitation launched as every year by the SIN and Davivere ETS,
18:16about 110 Italian cities have illuminated squares, hospitals, schools and monuments in purple,
18:21the color of prematurity.
18:23But not only.
18:24Also this year the purple kit for prenatal neonates has been planned,
18:27a digital collection of all the files of the 2024 awareness campaign.
18:33Diabetes
18:37Diabetes in Italy affects about 4 million people,
18:41a number destined to increase by 2040 when it could affect up to 10% of the population.
18:47Globally, by 2045, diabetes will affect an adult of 8.
18:52The pathology is constantly growing and on the occasion of the World Diabetes Day,
18:57which this year has as theme Diabetes and well-being,
19:00FESDI, the Italian Diabetic Society Federation against Diabetes,
19:04which includes SID, Italian Diabetic Society and AMD,
19:08Association of Diabetic Doctors,
19:10has launched the campaign Let's make a team around diabetes,
19:14which invites institutions, scientific societies and patients to join forces to face the common challenge.
19:20The word of order must be prevention.
19:22So prevention as regards type 2 diabetes, which is preventable,
19:26and that with correct lifestyles and fighting overweight and obesity,
19:32can be prevented.
19:34Prevention also for type 1 diabetes,
19:36even if in reality it is still inappropriate to talk about prevention of this,
19:39but we are talking about the prevention of diabetic ketoacidosis,
19:42which thanks to the new screening, which from 2025 will begin in all of Italy,
19:49will tend to cancel these outbreaks of type 1 diabetes in diabetic ketoacidosis,
19:54which is a very dangerous condition that can lead to death.
19:57In recent years, new drugs, innovative therapies and programs of therapeutic education
20:02have significantly improved the quality of life of patients.
20:06Innovation is certainly something that helps a lot of diabetologists
20:10in managing the diabetic patient.
20:13We expect a lot in terms of innovation,
20:17especially in terms of therapeutic innovation.
20:20For example, weekly insulin will certainly be a very important innovation,
20:26but there will also be double, triple agonists for weight loss,
20:36for glycemic reduction.
20:38So new, smart, intelligent insulins,
20:42also drugs that will help reduce weight, reduce glycemia
20:49and control cardiovascular risk factors,
20:52as well as the cardiovascular risk itself in diabetic patients.
20:56The campaign Let's make a team around diabetes
20:59was launched in Rome in the context of the official presentation
21:03of the World Diabetes Day 2024,
21:07at the end of which the Manifesto of the Rights of the Person with Diabetes
21:11and the Rights of the Individual and the Community will be presented.
21:14An important manifesto is our Bible, which we should all follow.
21:19If I have to decline this manifesto,
21:25I would say that it is necessary that there is uniformity
21:28throughout the national territory of the assistance to people with diabetes,
21:33access to new drugs, new therapies,
21:36which are fundamental elements to be able to have a good quality of life.
21:40Because what is important that the health care system must give us
21:45is that we must live well and not survive, but live well.
21:51This is the fundamental point.
21:57Until recently, patients with Lennox-Gastaut syndrome,
22:00a serious encephalopathy of the development of epilepsy
22:03that affects about a million people around the world,
22:06did not have drugs that could offer significant and long-term improvements.
22:10Today, thanks to the free route of AIFA, the reimbursement of fenfluramine,
22:14children's neuropsychiatrists in our country have available a therapeutic option
22:19capable of improving the health prospects of patients.
22:22Today we have this new drug available,
22:27which has shown significant effectiveness
22:32both in short-term trials
22:36and in in-open real-world treatments
22:41that have also been carried out for years.
22:45And we can say that at least 50% of patients who have taken this drug
22:54have had an extremely significant benefit.
22:59The mission of the reimbursement of fenfluramine
23:01plus the Lennox-Gastaut syndrome agreed by AIFA
23:04is for UCB Italy an important step.
23:06Because we are talking about a rare pathology
23:09in which the therapeutic outlook is not yet sufficient
23:13to meet the needs of these patients,
23:16because they typically do it with resistance.
23:19Fenfluramine can decisively and long-term reduce epileptic seizures
23:25and therefore contribute clearly to the quality of life of the patient and his family,
23:30but also to the whole picture of the comorbidities
23:34that are accompanied in this pathology.
23:38One of the most complex aspects in the management of the Lennox-Gastaut syndrome
23:42is the transition of the patient from the pediatric age to the adult age,
23:45a complex moment of transition
23:47that involves the change of the medical team that follows the patient.
23:50There would be a need for institutionalized paths
23:53in which the transition follows a path
23:57that certainly cannot be carried out in a single moment, in a single day.
24:02For example, with structured ambulatories
24:05that start in adolescence, around 14-15 years old,
24:08they provide the ambulatory with visits
24:12with the presence of the pediatric neuropsychiatrist,
24:14the neurologist and other professional figures
24:16such as the psychiatrist, the physiatrist,
24:18but also the social worker, in some cases the psychologist is very important,
24:22and slowly accompany the patient to move towards the adult environment.
24:32More than a million people in Italy suffer from depression,
24:36a pathology often underestimated
24:38that literally disrupts the life of those who live it and those who are close to it,
24:42but of which there is still too little talk.
24:45To shed light on this complex disease,
24:48Johnson & Johnson Innovative Medicine
24:50hosted the event at its Milanese headquarters
24:53in the Labyrinth of Depression.
24:55It is now time to make it clear
24:57that it has seen the participation of experts in the clinical sector
25:00and representatives of patient associations.
25:03Depression is a disease that accompanies a very high risk of suicide,
25:07around which there is a great stigma,
25:10there is little or too little talk,
25:12both from patients and relatives,
25:14and from employees.
25:16The psychiatrist is the right person to make a diagnosis
25:19and set up the therapy,
25:21which can then be done by the various professional figures involved,
25:24clearly the psychotherapist,
25:26the psychiatric rehabilitation technician
25:28and the other figures who can help.
25:31During the event organized by Johnson & Johnson Innovative Medicine,
25:35the Out of the Maze awareness campaign was presented,
25:39in addition to the Labyrinth of Depression,
25:41promoted by Johnson & Johnson,
25:43with the sponsorship of the Itaca ETS Foundation
25:47and Cittadinanza Attiva APS.
25:49The goal of this campaign is not only to raise public opinion
25:55on a mental health issue,
25:57but also to raise awareness
26:00that today it is possible to get out of the Labyrinth of Depression
26:06with a temporary diagnosis,
26:08an adequate intervention in specialized centers
26:12and therefore also a personalized diagnostic-therapeutic course.
26:17Supporter of the campaign, the former footballer Gigi Buffon.
26:21The figure I have in this case
26:25is a figure of great responsibility
26:28who can solicit in some cases,
26:33can help in others,
26:36can suggest in others still
26:39to all people who have certain pathologies
26:43that there is nothing wrong with having them.
26:47In all serenity, in all simplicity,
26:51to be able to report them
26:54and immediately find help
26:58that can help you
27:01and can accompany you in this path of healing.
27:10It was held on Tuesday, November 19 in Rome
27:12the new appointment of Active Principles,
27:14a cycle of events promoted by Böhringer Ingelheim Italia
27:18to address some of the most pressing priorities of public health,
27:22starting from the legal foundations
27:24up to the impact on patients, families and society.
27:27At the center of the meeting, the right to health.
27:30As a result of a pandemic,
27:32the debate on health was able to return to the center,
27:36on the need for necessary reforms
27:39for a better load-taking,
27:41to relaunch prevention,
27:43to relaunch territorial medicine,
27:45to guarantee a universal load-taking.
27:49Therefore, reforms are needed.
27:52Reforms that I think represent,
27:55for the transversality of the goals we must set,
27:59the great opportunity that the Parliament has
28:02to do something concrete, immediate, right,
28:06to save one of the peculiarities of our country.
28:09A season must be opened,
28:11consisting of necessary reforms,
28:14to put in safety one of the fundamental pillars,
28:17which is the right to health.
28:19The appointment, entitled
28:20The health of Italians between tradition, recovery and resilience,
28:23gave the opportunity to explain how the PNRR
28:26has led to an injection of investments and innovation.
28:29The issue of health is a central issue.
28:34In the PNRR there are important resources,
28:38I remind you that there are almost 14 billion resources,
28:43many also dedicated to territorial health.
28:48I think that the COVID experience,
28:52with all the negative effects,
28:54made it clear to all the administrations,
28:57both central and regional,
29:00how important health care is,
29:04and above all territorial health.
29:09The role of pharmacies and pharmacists remains fundamental,
29:12which can provide significant support to the system.
29:15I would say that the pandemic has clarified a context
29:19on which the Federation has already committed since 2005,
29:22that is, to strengthen the proximity
29:25to really think of a territorial assistance
29:28that can provide a response to patients.
29:31The bad experience of COVID has certainly
29:34enhanced the role of the pharmacist,
29:36who also thanks to the 2005 federal project
29:39began an evolution path that could make him
29:42always the protagonist of the dispensation,
29:45but also the protagonist of a new phase,
29:47what we then called the pharmacy of services
29:51of the poly-functional center available to citizens,
29:54but which is now called proximity.
29:56So I think we can do a lot, but not in words,
29:59but with facts, with the numbers of electrocardiograms
30:02that we do every day,
30:03with the number of heart and blood pressure
30:05that we apply,
30:06with the number of tampons,
30:07with the number of vaccinations.
30:09In short, a pharmacist who is able,
30:11thanks to the cultural evolution of these years,
30:13to give something more to the Italian population.
30:16What is the aim of the project?
30:20Early identification of the silent symptoms
30:23of multiple sclerosis,
30:24thanks to the analysis of the behavior of the patient
30:26in the use of the smartphone,
30:28through artificial intelligence.
30:30This is the aim of the winning project
30:32of the sixth edition of the Digital Innovation Award
30:35in Neurology,
30:36promoted by Merck with the sponsorship
30:38of the Italian Society of Neurology.
30:40To draw recognition,
30:41conferred in the context of the 54th Congress
30:44of the Scientific Society,
30:46Professor Pasquale Arpaia,
30:48Director of the project,
30:49at the Federico II University of Naples.
30:52Instead of using dedicated apps
30:54that bore the patient,
30:56from the daily interaction
30:58with the already native cell phone apps,
31:01sending a WhatsApp SMS,
31:04writing messages,
31:07then the patient who has these silent symptoms
31:10obviously experiences difficulties,
31:13small hiccups, delays,
31:15difficulty in typing.
31:17Artificial intelligence inside the cell phone
31:20realizes this difficulty
31:24and provides useful support to the doctor.
31:29So, as always,
31:31in our actions of technology, innovation and medicine,
31:34the patient in the first place
31:36and then the doctor next to him.
31:38Technology at the service of man.
31:41Committed for more than 30 years
31:43in the research and development
31:44of transformative drugs for patients,
31:46today Merck also works to create
31:48innovative technological solutions
31:50that can help doctors to understand
31:52daily the evolution of the disease
31:54of their patients.
31:56For this reason, this year we have reached
31:58the 6th edition of the award
32:00of digital and technological innovation of Merck,
32:03aimed at finding projects
32:08that can solve this problem
32:11of being able to monitor patients constantly.
32:14We know that the disease with multiple sclerosis
32:18is a disease that evolves
32:20especially with the so-called silent symptoms,
32:23but in reality very often
32:25these silent symptoms are not taken from the clinic
32:28because they are subtle
32:30and there is no adequate technology
32:32to be able to monitor these aspects.
32:35Thanks to today's technological and digital innovations,
32:40thanks to artificial intelligence,
32:42we can really provide the clinic
32:45with information that can have an immediate mirror
32:48of what is the state of evolution
32:50of a patient's disease.
32:51To slow down the progression of multiple sclerosis,
32:54Merck has developed Cladribina,
32:56with its high effectiveness,
32:57ease of supply
32:59and optimal safety profile.
33:01Cladribina is an innovative and very interesting
33:04drug that we define as immune-replacing.
33:07What does immune-replacing mean?
33:09It means that the drug is able to deplete,
33:12therefore to kill,
33:13lymphocytes B and lymphocytes T,
33:15which are the ones that subsequently attack the myelin
33:18and therefore determine the tissue damage
33:20and the progression of disability.
33:22After the assumption of Cladribina,
33:24these lymphocytes B and these lymphocytes T
33:26tend to be significantly reduced
33:30and the myeloid begins to reconstruct
33:33new lymphocytes B and new lymphocytes T,
33:35which in theory do not have memory against the myelin
33:38and therefore we are able, over time,
33:40to control the aggression of these cells on the myelin
33:45and to control the progression of disability.
33:52This was our latest news.
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